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35 Percent Decline in Cognitive Slowdown: More Alzheimer’s Treatments in Pipeline

Alzheimer's Treatments in Pipeline

United States: The Alzheimer’s Association just put out its 2024 Facts and Figures report on Alzheimer’s disease. It provides new insights regarding the latest treatments and tips on how dementia caregivers are heading.

Reports findings in brief

The study brings to the fore that we have severe workforce shortages.

According to the report, Texas has a large number of 333 physicians trained in geriatrics who serve to provide care for the 459 thousand people 65 and above who have been diagnosed with Alzheimer’s as well as other geriatric conditions.

Already, by 2050, it was projected that 276.9 percent more geriatric physicians would be needed in geriatric medicine based on that study.

In the next six years, we will need 30.5 percent more personal care aids and home health workers in Texas than in the existing ones.

According to a panel on dementia at South by Southwest, the following findings are learned from the reports, as aol.com reported.

Number of Alzheimer’s cases

Visual Representation of Alzheimeri’s Test Look. Credit | Getty images

In Texas, about 11.9 percent of the population is one being 65 years old or older. Nationally, it amounted to 10.9 percent.

More women than men have Alzheimer’s: 9 percent of male and 11 percent of female patients 65 years of age and upwards.

A single study supposed that females who reach 45 years old have an approximately 20 percent lifetime risk for Alzheimer’s, while men’s risk is 10 percent.

The rates also vary by race: Through the relation to people that are 65 or older who are black, the percentage of Alzheimer’s disease is highest at 19 percent compared to Hispanic people, which is 14 percent, and white people, which is 10 percent.

In the US alone, Alzheimer’s is now the sixth leading cause of which the mortality rate is among. The figure went from 2000 to 2021 from 140.9 percent. Meanwhile, this is controversial to people who think that more people die of heart disease and stroke because it is already widespread annually, according to aol.com.

More than one form of dementia in most patients

Visual Representation of Dementia. Credit | Getty images

Many patients with dementia have more than one form. A review of autopsy reports from patients with Alzheimer’s disease indicated that only three percent had Alzheimer’s alone.

However, 15 percent of the cases were of a kind of dementia that was not Alzheimer’s, while 82 percent of the cases were mixed kinds.

The only perfect basis for diagnosis is an autopsy itself, however, some specialized research is already aimed at creation of more testing tools.

Present status of available treatments

We currently have two disease-modifying medications that have been approved by the Food and Drug Administration (FDA), these are lecanemab-irmb, under the brand name Leqembi, and aducanumab-avwa, which is branded as Aduhelm.

Additionally, Adhelm is being discontinued in November because Leqembi has been more effective.

Such medicines target the amyloid beta plaques, which are the result of the interaction of amyloid protein, as aol.com reported.

The effectiveness of Leqembi has been proved in clinical trials, where it showed a 27 percent decrease in cognitive slowdown.

Now, eight months later, after FDA approval, the infusions are showing the same results in the individual Leqembi patients.

Meanwhile, the pharmaceutical industry is busily working on even more drugs like these into the pipeline. For example, Eli-Lilly is in the final stages of getting approval for Donanemab. The organization claims that this drug slows down the abrupt change in one’s cognition decline by 35 percent. The approval is likely to come this year, the source added.

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