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BREAKTHROUGH: Human sweat can fight against tick-borne Lyme disease, raises hope!

Human sweat can fight against tick-borne Lyme disease

United States: It appears that the Lyme disease fight may have just gotten a new hope: the tick-borne infection that may even result in a chronic illness.

About the study

Under investigation by scientists at MIT and the University of Helsinki, the protein in the human sweat is found to be the antagonist for the bacteria that is helping to cause the disease.

The research results were published in journal Nature Communications indicate that one-third of the population carries the genetic variation of this protein, as such.

Michal Caspi Tal, a principal research scientist in MIT’s Department of Biological Engineering and one of the senior study authors, said, “This protein may provide some protection from Lyme disease, and we think there are real implications here for a preventative and possibly a therapeutic based on this protein,” the New York Post reported.

The scientists studied two types of results from the experiment prospect including, the genetic material and medical hostories, extracted from the blood of 7,000 Finnish people who had contracted the disease and were undergoing treatment.

What did the scientists observe?

They were surprised to detect a secretoglobin called SCGB1D2 that surpassed bacteria in growth in their next vital outcomes.

Secretoglobins are proteins that were found to decrease lung damage. This compound showed an interesting feature of being released by sweat gland cells.

During the course of this research, investigators incubated normal and disease-associated SCGB1D2 with Lyme disease-carrying intracellular bacterium Borrelia burgdorferi.

They report that bacteria grew almost entirely in the case of the normal laboratory protein, while twice the amount of the mutated was needed to get similar results.

SCGB1D2 is the mouse protein that was mutated in the experiment and its expression in other mice infected with the disease but expressing the mutated protein did not cause Lyme disease.

Tal said, “In the paper, we show they stayed healthy until day 10, but we followed the mice for over a month, and they never got infected,” and, “This wasn’t a delay; this was a full stop. That was really exciting.”

Whether using the researchers in Estonia’s data of 18,000 people with Lyme disease even only by a simple replication, they find the same result.

To say the least, they do not understand how this SCGB1D2 inhibits bacterial action and why this exon is less efficient due to the wrong sequence.

Protein is now used to manufacture skin creams to prevent that disease from happening and to cure antibiotic-resistant infections.

Tal said, “We have fantastic antibiotics that work for 90% of people, but in the 40 years we’ve known about Lyme disease, we have not budged that,” as the New York Post reported.

Further added, “10% of people don’t recover after having antibiotics, and there’s no treatment for them,” said Tal.

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